Prediction of Outcomes Following Total Knee Replacement
Completed
Conditions studied: Osteoarthritis
In brief
This is an observational study (not a treatment study) of pain and physical functioning after total knee replacement. The study includes 5 visits, 1 before surgery and 4 after surgery. You may be eligible if you are 50 or older,will soon be undergoing knee replacement surgery, do not have a serious heart condition or certain other medical conditions, and are not taking certain types of medications. The study includes evaluation of peoples' pain, physical functioning, medication use, and physiological responses to sensory stimuli such as heat and cold.
Key facts
- Study ID
- NCT01370421
- Run by
- Brigham and Women's Hospital
- People needed
- 248
- Starts
- 2011-04-01
- Expected to finish
- 2019-03-01
- Last updated by the study team
- 2022-03-02
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 50 or older
- Meet the American College of Rheumatology criteria for knee osteoarthritis
- Scheduled to undergo total knee arthroplasty
- Facility with the English language that is adequate to complete study procedures
You may not qualify if…
- Cognitive impairment preventing completion of study assessment procedures
- Myocardial infarction within the past 12 months
- Severe raynaud's or severe neuropathy
- Active vasculitis or severe peripheral vascular disease
- Current infection
- Use of oral steroids
- Recent history of substance abuse or dependence
- Confirmed diagnosis of periodic limb movement disorder or restless legs syndrome
- Systemic inflammatory or autoimmune disorders such as rheumatoid arthritis, lupus, etc.
- Known anemia
Where it is running
- Brigham and Women's Hospital — Chestnut Hill, Massachusetts, United States
Full record on ClinicalTrials.gov
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