Study Of Single Doses Of PF-06291826 (Tafamidis) In Japanese And Western Subjects

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

The purpose of this study is the following: * To evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered tafamidis in Japanese and Western healthy volunteers at single dose. * To compare Japanese and Western PK profiles. * Determine the PD stabilization effect of tafamidis on human transthyretin (TTR) in a validated ex vivo assay.

Key facts

Study ID

NCT01369836

Run by

Pfizer

People needed

21

Starts

2011-07-01

Expected to finish

2011-08-01

Last updated by the study team

2011-09-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male or females.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2.

You may not qualify if…

• Pregnant or nursing females.
• Females of childbearing potential who are unwilling or unable to use an acceptable method of contraception.

Where it is running

• Pfizer Investigational Site — Glendale, California, United States

Full record on ClinicalTrials.gov

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