Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's Disease

Completed · Phase 1

Conditions studied: Alzheimer's Disease

In brief

This is a study to evaluate the safety and tolerability of multiple doses of AAB-003 (PF-05236812) in patients with mild to moderate Alzheimer's Disease. Patients who complete study B2601001 may participate in this trial and receive AAB-003 (PF-05236812). Each patient's participation will last approximately 52 weeks.

Key facts

Study ID

NCT01369225

Run by

Pfizer

People needed

52

Starts

2011-07-01

Expected to finish

2014-08-01

Last updated by the study team

2017-03-10

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Successful completion of study B2601001
• MMSE 12 or greater

You may not qualify if…

• Study B2601001 Week 32 MRI with clinically important exclusionary findings.
• Experienced SAE, vasogenic edema and/or intracranial hemorrhage in study B2601001

Where it is running

• MD Clinical — Hallandale, Florida, United States
• Munroe Regional Medical Center — Ocala, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• Trinity Care Solutions — Ocala, Florida, United States
• Advanced Imaging of Ocala — Ocala, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• Foers Medical Arts Pharmacy — Bethesda, Maryland, United States
• CBH Health, LLC — Rockville, Maryland, United States
• Borgess Medical Center — Kalamazoo, Michigan, United States
• Borgess Research Institute — Kalamazoo, Michigan, United States
• KNI Southwest Michigan Imaging Center, LLC — Kalamazoo, Michigan, United States
• Millennium Psychiatric Associates, LLC — Creve Coeur, Missouri, United States
• DePaul Health Center-MRI Department — St Louis, Missouri, United States
• Memory Enhancement Center of America, Inc. — Eatontown, New Jersey, United States
• Central Jersey Radiology — Oakhurst, New Jersey, United States
• Seoul National University Hospital, Department Neurology — Seongnam-si, Gyeonggi-do, South Korea
• Inha University Hospital, Department of Neurology — Incheon, South Korea
• Samsung Medical Center, Department of Neurology — Seoul, South Korea
• Korea University Anam Hospital IRB — Seoul, South Korea
• ASAN Medical Center — Seoul, South Korea
• Konkuk University Medical Center, Department of Neurology — Seoul, South Korea

Full record on ClinicalTrials.gov

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