Intensive Cognitive-Behavioral Therapy For Obsessive-Compulsive Disorder

Completed · Not applicable

Conditions studied: Obsessive-Compulsive Disorder (OCD)

In brief

Even with the best available treatments for obsessive-compulsive disorder (OCD), most patients only partially recover and many patients do not respond at all. Such incomplete and inadequate response contributes to greater public health costs in terms of morbidity and patient care expenses. This study aims for a better understanding of abnormal brain chemistry in OCD and how it is affected by cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. The main hypothesis is that CBT will change levels of the excitatory neurotransmitter glutamate in OCD patients in a region of the brain involved in OCD known as the cingulate cortex.

Key facts

Study ID

NCT01368510

Run by

University of California, Los Angeles

People needed

75

Starts

2011-07-01

Expected to finish

2015-06-01

Last updated by the study team

2020-03-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• meets DSM-IV-TR diagnostic criteria for OCD as primary (most severe) diagnosis based on Anxiety Disorders Interview Schedule (ADIS) Clinical Severity Rating
• reported DSM-IV-TR-threshold OCD symptom onset age 18 or later
• Yale-Brown Obsessive-Compulsive total score greater than or equal to 16
• fluent English speaker
• signed informed consent

You may not qualify if…

• IQ of less than 80 on the Wechsler Abbreviated Scales of Intelligence
• lifetime DSM-IV diagnosis of pervasive developmental disorder, mania, psychosis, conduct disorder, or substance dependence assessed through ADIS
• current DSM-IV diagnosis of major depressive disorder if ADIS CSR rating is 4 or higher (severe) or attention-deficit hyperactivity disorder
• primary compulsive hoarding
• any changes (dose or agent) in psychotropic medication for OCD or other psychiatric condition within 12 weeks prior to enrollment
• severe illness that requires immediate inpatient psychiatric intervention
• any serious psychiatric, psychosocial, or neurological condition requiring immediate treatment other than that provided in the current study
• any body metal (other than dental fillings), positive pregnancy test, or other MR scan contraindications
• prior trial of CBT for OCD, regardless of outcome
• medical conditions that affect cerebral metabolism (e.g., thyroid disorders or diabetes)

Where it is running

• UCLA Obsessive-Compulsive Disorder Intensive Treatment Program — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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