Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions

Completed · Phase 2 · Has a placebo group

Conditions studied: TBI, Major Depression, Other Psychiatric Disorders

In brief

This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).

Key facts

Study ID

NCT01368432

Run by

Johns Hopkins University

People needed

16

Starts

2010-04-01

Expected to finish

2013-03-01

Last updated by the study team

2016-10-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Closed head injury
• Fulfill Diagnostic and Statistical Manual Diploma in Social Medicine (DSM) IV criteria "Major Depressive Disorder"
• 18 years of age or older
• Able to provide informed consent
• Stable medical history

You may not qualify if…

• History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases
• History of mental retardation
• Alcohol or Substance dependence in the last 1 year
• Inability to undergo MRI scan
• Pregnancy
• Current use of any psychotropic medications including any antidepressants, antipsychotics, anxiolytics, or sedative hypnotics
• Poor response to escitalopram in the past
• Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by the study psychiatrist
• Good medication response to another antidepressant in the past

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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