Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome

Completed · Not applicable

Conditions studied: Turner Syndrome

In brief

The purpose of this research study is to learn about brain development in very young girls with Turner syndrome (TS) and the effect that growth hormone (GH) therapy has on early brain development.

Key facts

Study ID

NCT01367834

Run by

Rebecca Knickmeyer Santelli, PhD

People needed

17

Starts

2010-05-01

Expected to finish

2014-05-01

Last updated by the study team

2017-03-24

Who can join

Age: 1 and older, up to 1. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Turner syndrome
• Less than the 50th percentile for length for the general female population

You may not qualify if…

• Prior Growth Hormone (GH) therapy
• Diabetes
• Allergy to metacresol (a preservative in the GH liquid that is injected)
• Contraindications for Magnetic Resonance Imaging (MRI) (such as metal in the body)
• Part of a Y chromosome in child's karyotype
• Parent/guardian is not willing for child to be randomized to be in the treatment group (receives Growth Hormone injections for one year) or the control group (receives no Growth Hormone during the study)
• Parent/guardian is not willing for child to have some of her developmental testing digitally recorded for scoring

Where it is running

• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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