Cognitive Dysfunction in Postural Tachycardia Syndrome
Completed
Conditions studied: Postural Tachycardia Syndrome
In brief
A common complaint among people with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This is very poorly understood. To better understand this cognitive dysfunction, the investigators will test people with POTS and people without POTS using various neuropsychiatric instruments. The investigators hypothesis is that people with POTS will have greater abnormalities on neuropsychiatric testing than normal controls.
Key facts
- Study ID
- NCT01366963
- Run by
- Vanderbilt University
- People needed
- 60
- Starts
- 2011-03-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2016-08-17
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All
- Ages between 18-60 years
- Male and female subjects are eligible
- Able and willing to provide informed consent
- POTS - additional inclusion criteria - Diagnosed with postural tachycardia syndrome by Vanderbilt Autonomic Dysfunction Center (increase in heart rate greater than or equal to 30 beats per minute with position change from supine to standing (10 minutes; chronic symptoms consistent with POTS that are worse when upright and get better with recumbence.)
- Control subjects - additional inclusion criteria
- Gender matched to POTS patients
- Age-matched to POTS patients (+/- 5 years of a POTS patient)
- Grossly matched in intelligence to POTS patients
You may not qualify if…
- ALL
- Inability to give or withdrawal of informed consent
- Pregnancy (determined by patient self report)
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol.
- POTS - additional exclusion criteria
- Overt cause for postural tachycardia (such as acute dehydration)
- Normal Controls - additional exclusion criteria
- Previously diagnosed with Axis I psychiatric disorder
- Previously diagnosed learning disorder
- Previously diagnosed attention deficit hyperactivity disorder (ADHD)
- Prior psychosis
- past or present substance abuse
- History of loss of consciousness
- History of seizures
Where it is running
- Vanderbilt University — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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