Inflammatory Biomarkers Predict Pulmonary Outcomes in Coronary Artery Bypass Grafting
Completed
Conditions studied: Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
In brief
The primary objective of this pilot study is to identify and quantify inflammatory and genetic markers from bronchoalveolar lavage fluid (BALF) and serum in patients with a history of chronic obstructive pulmonary disease (COPD) undergoing elective coronary revascularization (CABG) to determine the risk of developing post operative respiratory failure. To achieve this objective, this proposal outlines the following specific aims: Aim #1. To identify from BALF and serum, the change in inflammatory and genetic markers in patients with a history of COPD undergoing CABG. BALF and serum samples will be obtained at the time of intubation immediately prior to surgery and again upon skin closure immediately after the surgical procedure. Aim #2. To determine the extent to which inflammatory and/or genetic markers correlate with post-operative pulmonary complications defined as prolonged mechanical ventilation (\> 24 hours), pneumonia, and/or tracheostomy. Aim #3. To inform the development and implementation of a large pivotal trial which may impact clinical decision-making during the initial pre-operative outpatient assessment of COPD patients undergoing CABG.
Key facts
- Study ID
- NCT01366469
- Run by
- Emory University
- People needed
- 10
- Starts
- 2011-04-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-02-19
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Undergoing elective CABG
- Current diagnosis of COPD
- Ability to provide signed informed consent to participate
- > 18 years of age
You may not qualify if…
- Concomitant valve surgery
- Urgent or emergent coronary surgery
- Current steroid therapy
- Active smoker and/or positive urine co-nicotine
Where it is running
- Emory University Hospital Midtown — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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