Unrelated Donor Stem Cell Transplantation

Completed · Not applicable

Conditions studied: Severe Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Myeloproliferative Syndromes, Chronic Myelogenous Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Large Granulocytic Leukemia

In brief

The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.

Key facts

Study ID

NCT01364363

Run by

Scripps Health

People needed

64

Starts

2005-03-01

Expected to finish

2015-07-01

Last updated by the study team

2022-11-23

Who can join

Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 18 years of Age
• < 70 years
• ECOG performance status 0, 1 or 2
• Left Ventricular Ejection Fraction > 30%
• Creatinine clearance > 40ml/min
• Transaminases < 2X normal
• Total bilirubin < 2X normal
• HIV seronegativity
• Weight < 70kg for cord blood transplantation
• Ability to cover the cost of the transplant, necessary medications, and transportation/housing.
• Caregiver must be available while outpatient

You may not qualify if…

• Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at HLA-A, B, C or DR

Where it is running

• Scripps Green Hospital — La Jolla, California, United States

Full record on ClinicalTrials.gov

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