The Effects of Caffeinated Coffee on Intraocular Pressure

Completed · Not applicable

Conditions studied: Primary Open Angle Glaucoma

In brief

High intraocular pressure (IOP) is a known risk factor for developing primary open-angle glaucoma (POAG). There is controversy in the literature regarding the degree to which caffeine influences IOP, with some studies reporting minimal changes in IOP while others report up to 4 mmHg increases. To date there are no double-masked randomized controlled trials that examine acute caffeinated coffee's effects on IOP in patients with or at risk for primary open-angle glaucoma. The investigators aim to better understand the relationship between acute caffeinated coffee (vs decaffeinate coffee) consumption and IOP in a double-masked, crossover randomized controlled clinical trial.

Key facts

Study ID

NCT01364207

Run by

Massachusetts Eye and Ear Infirmary

People needed

112

Starts

2010-11-01

Expected to finish

2012-06-01

Last updated by the study team

2012-10-31

Who can join

Age: 40 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 40-89 yrs
• POAG for cases or no forms of glaucoma for controls
• Willingness to drink coffee
• Consent signed

You may not qualify if…

• Age less than 40 or greater than 89 yrs
• all forms of glaucoma other than POAG
• any condition inappropriate for tonometry (ie corneal disease, LASIK)
• unable or unwilling to give consent
• unable or unwilling to drink coffee
• pregnancy

Where it is running

• Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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