Safety and Pharmacokinetics of Escalating Doses of DNIB0600A in Participants With Non-Small Cell Lung Cancer (NSCLC) and Platinum Resistant Ovarian Cancer

Completed · Phase 1

Conditions studied: Non-Small Cell Lung Cancer, Ovarian Cancer

In brief

Study DNB4987g is a Phase I, multicenter, open label, dose-escalation study of DNIB0600A administered as a single agent by intravenous (IV) infusion every three weeks (q3w) to participants with non-squamous NSCLC or non-mucinous, platinum-resistant ovarian cancer. The study will be conducted in two cohorts: Dose-escalation cohort and Expansion cohort.

Key facts

Study ID

NCT01363947

Run by

Genentech, Inc.

People needed

87

Starts

2011-06-14

Expected to finish

2016-06-03

Last updated by the study team

2017-06-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Histologic documentation of incurable, locally advanced or metastatic disease that has failed prior chemotherapy and for which no standard therapy exists, including the following: non-squamous NSCLC or non-mucinous and platinum-resistant ovarian cancer
• Availability and willingness to provide an adequate archival sample of tumor
• Measurable disease
• For fertile men or women of childbearing potential, documented willingness to use a highly effective means of contraception

You may not qualify if…

• Anti-tumor therapy, including chemotherapy, biologic, experimental, or hormonal therapy within 4 weeks prior to study treatment
• Major surgical procedure within 4 weeks prior to study treatment
• Known active bacterial, viral, fungal, mycobacterial, or other infection (including human immunodeficiency virus [HIV] and atypical mycobacterial disease, but excluding fungal infections of the nail beds)
• Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis
• Untreated or active central nervous system (CNS) metastases
• Requirement for supplemental oxygen to carry out activities of daily living
• Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the participant at high risk from treatment complications
• Evidence of significant uncontrolled concomitant diseases, such as cardiovascular disease, nervous system, pulmonary, renal, hepatic, endocrine, or gastrointestinal disorders; or a serious non-healing wound or fracture
• For participants in the second NSCLC cohort expansion, not more than two prior regimens in the metastatic setting
• Pregnancy or breast-feeding

Where it is running

• HonorHealth Research Institute - Pima Center — Scottsdale, Arizona, United States
• Smilow Cancer Hospital at Yale New Haven — New Haven, Connecticut, United States
• Sarah Cannon Research Inst. — Nashville, Tennessee, United States
• Univ of Texas SW Medical Ctr — Dallas, Texas, United States
• Hospital del Mar; Servicio de Oncologia — Barcelona, Spain
• Hospital Univ Vall d'Hebron; Servicio de Oncologia — Barcelona, Spain
• Hospital General Universitario Gregorio Marañon; Servicio de Oncologia — Madrid, Spain

Full record on ClinicalTrials.gov

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