Prevention of Photoparoxysmal Abnormalities by Mozart K448

Stopped early · Not applicable

Conditions studied: Photoparoxysmal Abnormalities, Epilepsy, Seizures

In brief

The purpose of this clinical trial is to examine the effect of non-invasive cortical activation by specific patterned auditory stimulation (Mozart K448- Piano Sonata for Two Hands in D Major), in altering or eliminating photoparoxysmal abnormalities. Recent work has indicated that such evoked activity (i.e. by specific music) can result in significant reductions, or even complete termination of epileptiform activity and/or seizures across a broad range of individuals with epilepsy. A hypothesis is generated that specific music activation would beneficially effect photoparoxysmal based epileptiform abnormalities.

Key facts

Study ID

NCT01363154

Run by

Medical University of South Carolina

People needed

10

Starts

2010-11-01

Expected to finish

2013-02-01

Last updated by the study team

2013-06-04

Who can join

Age: 5 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 5-17 years, inclusive
• Female or male with photoparoxysmal epilepsy clinical history, and at least one seizure, as defined by the International League Against Epilepsy (International Classification of Epilepsies and Epileptic Syndromes; Commission on Classification and Terminology of the International League Against Epilepsy 1989)
• Abnormal EEG consistent with features of photoparoxysmal epilepsy: occipital based epileptiform abnormalities with otherwise normal background interictal EEG;
• On < or equal to 2 anti-seizure medications [range 0-2 AEDs]

You may not qualify if…

• History of a generalized convulsion provoked by photic stimulation;
• Inability to complete and/or comply with study protocol

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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