Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation

Completed · Phase 3

Conditions studied: Persistent Atrial Fibrillation

In brief

The purpose of this prospective randomized study is to assess whether empirical Left Atrial Appendage (LAA) isolation along with the standard approach of pulmonary vein isolation (PVI) and ablation of extra-pulmonary triggers is superior to the standard approach alone in enhancing the long-term success rate of catheter ablation in persistent or long-standing persistent atrial fibrillation (AF) patients.

Key facts

Study ID

NCT01362738

Run by

Texas Cardiac Arrhythmia Research Foundation

People needed

156

Starts

2010-11-01

Expected to finish

2016-11-01

Last updated by the study team

2017-04-26

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-75 years
• History of PeAF or LSP AF refractory to antiarrhythmic drugs
• Willing and ability to understand and sign an informed consent

You may not qualify if…

• Reversible causes of AF (hyperthyroidism)
• Left atrial thrombus
• Moderate to severe valvular heart disease
• Contraindication for anticoagulation
• Life expectancy < 12 months
• Pregnancy

Where it is running

• St. David's Medical Center — Austin, Texas, United States
• Texas Cardiac Arrhythmia Research Foundation — Austin, Texas, United States

Full record on ClinicalTrials.gov

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