National Marrow Donor Program Long-Term Donor Follow-Up

Completed

Conditions studied: Hematologic Neoplasms

In brief

This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized PBSC donors.

Key facts

Study ID

NCT01362179

Run by

Center for International Blood and Marrow Transplant Research

People needed

21974

Starts

2010-10-01

Expected to finish

2020-10-15

Last updated by the study team

2020-10-20

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unrelated donor who donated either unstimulated BM or filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation.
• Unrelated donor who received at least one injection of filgrastim or more, but did not donate filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation.
• Donation was managed by a U.S. NMDP donor center.
• Signed informed consent for participation in this long-term donor follow-up study. Concurrent enrollment on other studies is permitted.

You may not qualify if…

• Unrelated donor who donated filgrastim-mobilized bone marrow.
• Donation was managed by a non-U.S. donor center.
• Donor is unable to verbally communicate in any of the following languages: English, Spanish, Mandarin Chinese, Cantonese Chinese, Vietnamese, Korean, or Portuguese.

Where it is running

• City of Hope — Duarte, California, United States
• National Marrow Donor Program Northern California & Northwest District — Oakland, California, United States
• National Marrow Donor Program Southern California & Southwest District — Santa Ana, California, United States
• Colorado Marrow Donor Program — Denver, Colorado, United States
• OneBlood — Fort Lauderdale, Florida, United States
• Hawaii Bone Marrow Donor Registry — Honolulu, Hawaii, United States
• LifeSource — Glenview, Illinois, United States
• Rock River Valley Blood Center — Rockford, Illinois, United States
• Indiana Blood Center — Indianapolis, Indiana, United States
• National Marrow Donor Program Southcentral District, Heart of America — Leawood, Kansas, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Michigan Blood — Grand Rapids, Michigan, United States
• The HLA Registry — Oradell, New Jersey, United States
• New York Blood Center — Brooklyn, New York, United States
• DKMS Americas — New York, New York, United States
• National Marrow Donor Program Southeast District — Charlotte, North Carolina, United States
• National Marrow Donor Program Northcentral District — Cleveland, Ohio, United States
• Oklahoma Blood Institute — Oklahoma City, Oklahoma, United States
• National Marrow Donor Program Northeast District — Philadelphia, Pennsylvania, United States
• Rhode Island Blood Center — Providence, Rhode Island, United States
• Blood Assurance, Inc. — Chattanooga, Tennessee, United States
• Cooperative Appalachian Marrow Program Medic Regional Blood Center — Knoxville, Tennessee, United States
• Baylor Research Institute — Dallas, Texas, United States
• Cook Children's — El Paso, Texas, United States
• Gulf Coast Regional Blood Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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