Childhood Anesthesia and Cognitive Function

Completed

Conditions studied: Cognitive Deficits, Cognitive Ability, General

In brief

The purpose of this study is to determine whether pediatric anesthesia is associated with long-term hippocampal dysfunction

Key facts

Study ID

NCT01359215

Run by

University of California, San Francisco

People needed

30

Starts

2011-03-01

Expected to finish

2012-05-01

Last updated by the study team

2013-12-12

Who can join

Age: 6 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Anesthesia at less than 2 years of age
• Anesthetic time greater than 2 hours
• ASA I or II
• Induction with Propofol or Sevoflurane +/- N2O
• Maintenance with a volatile agent (sevoflurane, isoflurane, desflurane) +/- N2O

You may not qualify if…

• Neurosurgery
• Known genetic syndrome
• Any other anesthetic agents (ketamine, meperidine, barbiturates, etomidate, methoxyflurane, methadone, lorazepam)
• Low birthweight (<25%ile)
• Gestational age , 36 weeks
• color blindness
• h/o CNS disease
• cancer
• head trauma
• congenital heart disease
• ASA III or IV
• intra-operative hypotension (<30% baseline for > 5 min)
• Bradycardia (<30% baseline for > 5 min)
• Hypoxemia (Blood Oxygen Saturation <93% for > 5 min)
• Hypercarbia (pCO2 > 60 mm Hg > 5 min)
• Dysthermia (deviation from 36.5 deg C by > 1.5 deg C at any time)
• Puberty

Where it is running

• University of Califoria, Davis — Davis, California, United States
• Univeristy of California, San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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