Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)
Completed · Phase 4 · Has a placebo group
Conditions studied: Pulmonary Infections
In brief
To evaluate the effect of Dornase alfa on preterm and late preterm neonates with ventilator associated pulmonary infections. Dornase alfa has been effective in the treatment of pulmonary infections in patients with cystic fibrosis by aiding mucus clearance. The bacteria causing pulmonary infections in cystic fibrosis patients is similar to those infecting preterm infants. The investigators expect that dornase alfa therapy will improve recovery from ventilator associated pulmonary infections in preterm infants.
Key facts
- Study ID
- NCT01356147
- Run by
- Georgetown University
- People needed
- 11
- Starts
- 2011-05-01
- Expected to finish
- 2017-04-30
- Last updated by the study team
- 2018-08-07
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- infants less than 38 weeks gestation and over 7 days of age
- infants with a ventilator associated pulmonary infection, defined as intubated infants who have moderate to heavy White Blood Cells (WBCs) on tracheal aspirate, organisms on tracheal aspirate gram stain, a positive endotracheal tube culture, a chest x-ray with infiltrate, consolidation or atelectasis, an increase in oxygen (FiO2) requirement and whom the clinical team decides to treat with systemic antibiotic therapy
You may not qualify if…
- Extremely ill infants not expected to survive
- Critically ill infants requiring high frequency ventilation
- Infants with congenital pneumonia
- Infants with congenital malformations of the respiratory system (e.g. Congenital diaphragmatic hernia, cystic adenomatoid malformation or tracheo-esophageal fistula) Cyanotic congenital heart disease, chromosomal abnormalities and infants with a positive newborn screen for cystic fibrosis
Where it is running
- Georgetown University Hospital NICU — Washington D.C., District of Columbia, United States
- Georgetown University Hospital — Washington D.C., District of Columbia, United States
Full record on ClinicalTrials.gov
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