Resistance Exercise for the Prevention of Age-related Sarcopenia
Withdrawn before enrolling · Not applicable
Conditions studied: Sarcopenia
In brief
The purpose of this study is to determine the benefits of negative work progressive resistance exercise (PRE) for the conservative management of sarcopenia in older male Veterans at the DC VAMC. Efficacy will be assessed by examining post-exercise changes in metabolic and inflammatory markers, muscle morphology, strength, and functional status.
Key facts
- Study ID
- NCT01355861
- Run by
- US Department of Veterans Affairs
- People needed
- 0
- Starts
- 2011-06-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2015-06-26
Who can join
Age: 60 and older, up to 79. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Adult, ambulatory males > 60 years old (n=30) will be recruited for this proposed study. Participant inclusion criteria also includes having clinically significant sarcopenia based on the body composition assessment showing an aLM that is < 2 SD below the mean values of a young adult reference group using DEXA scanning.
You may not qualify if…
- Exclusion criteria include BMI scores > 30 or a Mini-Mental Status exam score of < 22. The second tier of screening will include the following blood tests, obtained between 8-9 AM, following a 12-hour overnight fast: CBC, routine chemistry profile (e.g., glucose, kidney and liver function tests). Veterans with an elevated fasting blood glucose by WHO criteria (FBG >110 mg/dl), triglyceride levels > 200 mg/dL, and/or known DM, or abnormalities of other routine blood tests (i.e., > 2 SD beyond normal) will be excluded from the study. Uncontrolled cardiovascular disease, non-ambulatory status, evidence of a major disease exacerbation over the last six months, and current participation in a supervised exercise program (minimum of three months, twice per week) would also preclude participation in this study.
Where it is running
- VA Medical Center, DC — Washington D.C., District of Columbia, United States
Full record on ClinicalTrials.gov
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