Effects of Positive Energy Balance and Exercise on Appetite Hormones in Sedentary Men and Women
Completed · Not applicable
Conditions studied: Appetite and General Nutritional Disorders
In brief
The purpose of this research study is to examine the effects of overfeeding and exercise on blood levels of hormones associated with regulating appetite, also thought of as feelings of hunger and satiety (fullness). Previous studies have shown that non-obese people have different amounts of these hormones in their blood compared to obese people. The investigators hypothesize that exercise will promote improved insulin sensitivity and corresponding beneficial changes in obese individuals. The investigators predict exercise induced changes in 24-hour plasma hormone levels will be associated with improved appetite during overfeeding in obese individuals.
Key facts
- Study ID
- NCT01354600
- Run by
- University of Wisconsin, Madison
- People needed
- 13
- Starts
- 2009-05-01
- Expected to finish
- 2012-02-01
- Last updated by the study team
- 2013-07-23
Who can join
Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy body mass index (BMI) = 19 < 25 kg/m2
- Obese BMI = 30 < 35 kg/m2
- Activity level = sedentary: Total energy expenditure/resting metabolic rate < 1.6 (average US adult level)
You may not qualify if…
- Tobacco use
- Regular exercise or physical activity, defined as > 2h/week of moderate to vigorous activity;
- Individuals who do not eat breakfast
- Weight loss of > 3% of body weight over the previous six months
- Eating a special diet (e.g., vegetarian or low-carbohydrate)
- Current diagnosis of, or using prescription medications for, thyroid dysfunction, type I or type II diabetes, hypertension, cardiovascular, kidney, or liver disease;
- Taking other prescription medications or over-the-country products that alter energy metabolism (other than birth control pills)
- Allergies to any of the foods used in the study
- Individuals who donated blood within 8 weeks prior to enrollment or who plan to give blood during the course of the study
- Claustrophobia
- History of exercise intolerance, including diagnosed exercise induced asthma or any physical limitations to seated cycling aerobic exercise
- Blood chemistries in excess of 130% of the upper normal level and/or hemoglobin or hematocrit below the normal range.
- Females that are pregnant (pregnancy status to be tested at the beginning of each 6-day metabolic chamber stay), lactating, or have irregular menses
Where it is running
- University of Wisconsin Hospitals, Clinical and Translational Research Core (CTRC) — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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