N-Acetyl-Cysteine (NAC) in Early Phase Schizophrenia Spectrum Psychosis

Completed · Phase 2 · Has a placebo group

Conditions studied: Schizophrenic Psychoses

In brief

The investigators seek to examine the effect of add-on N-Acetyl-Cysteine (NAC) in the early phase of schizophrenia spectrum illness in collaboration with researchers Kim Do, PhD, and Philippe Conus, MD in Switzerland. Modifications of brain structure are thought to occur during the pre-illness phase and around the transition to psychosis. Therefore, studying new treatments that could target changes occurring during this period is of critical importance. Aims: Does add-on NAC treatment in early psychosis influence: * positive and negative symptoms * extrapyramidal side-effects of other medication * plasma concentration of glutathione * Mismatch Negativity, a physiological marker

Key facts

Study ID

NCT01354132

Run by

Beth Israel Deaconess Medical Center

People needed

20

Starts

2011-05-01

Expected to finish

2014-08-01

Last updated by the study team

2017-07-05

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Capacity to provide informed consent
• DSM IV TR diagnosis of schizophrenia, schizophreniform, schizoaffective
• Psychiatric and medical stability
• Prescribing clinician's premission to participate, assurance of medical stability
• Having met threshold criteria for psychosis on CAARMS (Comprehensive Assessment of at Risk Mental States Scale) Psychosis subscale
• Up to 12 months of antipsychotic treatment

You may not qualify if…

• Severe medical comorbidities
• Previous cerebral trauma
• Substance induced psychosis or organic psychosis
• Mental retardation
• NAC allergy
• Pregnancy, females and males planning pregnancy
• Treatment with antioxidants
• Insufficient command of English

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Massachusetts Mental Health Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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