TENS Effectiveness and Knee Osteoarthritis in Humans
Completed · Not applicable · Has a placebo group
Conditions studied: Knee Osteoarthritis
In brief
TENS is a non pharmacological intervention to control pain. Both high (\>50 Hz) and low (\<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and Walsh, 2003). Hyperalgesia, an increased response to a noxious stimuli, is one component of pain and occurs both at the site of injury, primary hyperalgesia, and outside the site of injury, secondary hyperalgesia. Recent studies in animals with arthritis of the knee show that low and high frequency TENS differentially modulate primary and secondary hyperalgesia. Therefore the investigators hypothesize that TENS will reduce hyperalgesia and pain with movement resulting in increased function.
Key facts
- Study ID
- NCT01354054
- Run by
- University of Iowa
- People needed
- 100
- Starts
- 2006-11-01
- Expected to finish
- 2009-06-01
- Last updated by the study team
- 2011-05-16
Who can join
Age: 30 and older, up to 95. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- diagnosis of medial compartment knee osteoarthritis
- 18 and 60 years of age
- being able to ambulate to the mail box and back
- stable medication schedule over the last three weeks
- pain rating > 3 on a 0-10 scale when verbally asked to rate knee pain in the weight bearing position
- normal L1-S2 dermatomal screen and normal great toe and thumb proprioception.
You may not qualify if…
- Knee surgery in the last six months
- Knee injection in the last four weeks
- serious medical condition, uncontrolled diabetes mellitus, hypertension
- dementia or cognitive impairment
- permanent lower extremity sensory
- prior TENS use
Where it is running
- University of Iowa — Iowa City, Iowa, United States
- Department of Physical Therapy Federal university of Sergipe — Aracaju, Brazil
- Health and Rehabilitation Science Research Institute, University of Ulster , UK — Newtownabbey, Northern Ireland, United Kingdom
Full record on ClinicalTrials.gov
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