Personalized Risk Identification and Management for Arrhythmias and Heart Failure by ECG and MRI

Completed

Conditions studied: Inpatients and Outpatients With Routine 12-lead ECG

In brief

Prevention of myocardial functional deterioration and sudden cardiac death among individuals of intermediate risk remains one of the most elusive frontiers of contemporary medicine. While most of these individuals are known to have had contact with the medical system, they are frequently not considered to be at high risk until far advanced along one or multiple disease processes leading to irreversible myocardial loss and electric instability. The goal of this proposal is to determine the prognostic power of combining specific measures of ventricular architecture, myocardial structure and electrical function for the early identification of individuals at risk to develop ventricular arrhythmias and progressive myocardial failure leading to severe cardiovascular outcomes and death.

Key facts

Study ID

NCT01353131

Run by

Johns Hopkins University

People needed

162

Starts

2010-05-01

Expected to finish

2016-10-01

Last updated by the study team

2018-11-06

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• general hospital population with routine 12-lead ECG with abnormal repolarization (wide QRS-T angle>100°) with validated measures of myocardial damage (Selvester QRS score>5)

You may not qualify if…

• LVEF <35%
• age>70 years
• eGFR<45mL/min
• no ICD or PM
• no high risk of dying within 3 years from cancer, end stage cardiac, pulmonary, immunologic or neurologic diseases

Where it is running

• Division of Cardiology, Johns Hopkins University School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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