More Frequent In-Center Hemodialysis in Pediatric End Stage Renal Disease

Completed · Not applicable

Conditions studied: Pediatric End Stage Renal Disease, Hemodialysis

In brief

A health kidney works 24 hours a day, 7 days a week to remove toxins and fluid from the body. Many children with permanent kidney failure undergo dialysis, a life saving procedure that takes the place of a kidney. Currently, many children with permanent kidney failure only receive dialysis treatments 3 days a week in the hospital dialysis clinic. Children on dialysis have a markedly reduced life expectancy, with a life span 40-50 years shorter than their healthy counterparts. Survival for these children has not improved over the last 20 years. These data indicate that the current dialysis treatment strategy is unacceptable. This research project will study if more frequent dialysis, performed 5 days per week, will improve the health of children with permanent kidney failure compared to the current treatment strategy. Children will be treated with both traditional and more frequent dialysis schedules to measure improvements in their health and well being.

Key facts

Study ID

NCT01352455

Run by

Children's Hospital of Philadelphia

People needed

7

Starts

2011-03-01

Expected to finish

2013-09-01

Last updated by the study team

2013-12-31

Who can join

Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current outpatient ESRD pediatric patients, 3-21 years old, receiving in-center chronic HD.
• Patients have to be on chronic HD for at least 2 months before eligibility

You may not qualify if…

• Patients with a scheduled (with a specific transplant date) kidney transplant in the next 6 months
• Patients scheduled to be switched to peritoneal dialysis in the next 6 months
• Patients currently receiving >3 days per week of hemodialysis
• Patients currently receiving >12 hours per week of hemodialysis
• Anyone <3 years of age would be excluded from the study, so our minimum anticipated patient weight would be about 11 kg
• Patients >21 years of age at enrollment
• Patients receiving concomitant peritoneal dialysis
• Patients with <2 months on chronic HD
• Patients with a temporary or femoral dialysis catheter
• Patients who are not hypertensive (both not on blood pressure medication and with a SBP <95th percentile for age, sex, and height)
• Patients enrolled in an investigational drug trial involving blood pressure medication or any other clinical trial potentially affecting the primary outcome of the study
• Patients listed for a deceased donor transplant will not be excluded.

Where it is running

• Cincinnati Childrens Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• The Hospital for Sick Children — Toronto, Canada

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.