MEK162 and RAF265 in Adult Patients With Advanced Solid Tumors Harboring RAS or BRAFV600E Mutations

Completed · Phase 1

Conditions studied: Advanced Solid Tumors

In brief

This is a multi- center, open-label, dose finding, Phase Ib study to be conducted in two stages: a dose escalation part to determine the maximum tolerated dose (MTD) safety and tolerability of concurrent administration of MEK162 and RAF265, followed by an expansion part to further assess the safety and preliminary anti-tumor efficacy of this oral combination within two separate patient populations: i) patients with advanced solid tumors harboring BRAFV600E mutations or ii) patients with advanced solid tumors harboring RAS mutations.

Key facts

Study ID

NCT01352273

Run by

Array Biopharma, now a wholly owned subsidiary of Pfizer

People needed

69

Starts

2011-06-01

Expected to finish

2013-09-01

Last updated by the study team

2020-09-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically or cytologically confirmed and non-resectable advanced solid tumors for which no further effective standard therapy exists.
• The patients' tumors must contain documented activating somatic BRAFV600E* , NRAS or KRAS mutations (except for pancreatic cancer)
• All patients enrolled MUST provide fresh or archival tumor samples at baseline to enable central confirmation of BRAF or KRAS/NRAS mutations
• Measurable, or non-measurable but evaluable disease as determined by RECIST
• Adequate bone marrow function
• Adequate hepatic and renal function
• Adequate cardiovascular function
• Negative serum β HCG test (female patients of childbearing potential only) within 72 hrs prior to first dose

You may not qualify if…

• Patients with a history of primary central nervous system tumors or brain metastases or who have signs/symptoms attributable to brain metastases and have not been assessed with radiologic imaging to rule out the presence of brain metastases
• Current evidence of retinal disease; or ophthalmopathy as assessed by ophthalmologic examination at baseline that would be considered a risk factor for CSR/RVO (e.g., optic disc cupping, visual field defects, IOP > 21 mm Hg)
• Impaired cardio-/vascular function or clinically significant cardiovascular diseases, including any of the following:
• History/evidence of acute coronary syndromes (including MI, unstable angina, CABG, coronary angioplasty, or stenting) ≤ 6 months prior to starting study drugs
• Thromboembolic event (DVT, CVA, PE) ≤ 6 months prior to starting study
• Symptomatic CHF, history or current evidence of clinically significant cardiac arrhythmia and/or conduction abnormality
• Uncontrolled arterial hypertension, defined as BP > 140/100 mmHg (average of 3 consecutive readings)
• History of melena, hematemesis or hemoptysis within the last 3 months
• Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test (> 5 mIU/mL)
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• H. Lee Moffitt Cancer Center & Research Institute Moffitt 4 — Tampa, Florida, United States
• Oregon Health & Science University OHSU 3 — Portland, Oregon, United States
• University of Utah / Huntsman Cancer Institute Huntman 2 — Salt Lake City, Utah, United States
• Pfizer Investigative Site — Edmonton, Alberta, Canada
• Pfizer Investigative Site — Montreal, Quebec, Canada
• Pfizer Investigative Site — Oslo, Norway
• Pfizer Investigative Site — Madrid, Spain
• Pfizer Investigative Site — Zurich, Switzerland

Full record on ClinicalTrials.gov

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