Diffusion Weighted Imaging Evaluation for Understanding Stroke Evolution Study-2 (DEFUSE-2)
Completed
Conditions studied: Cerebrovascular Accident
In brief
Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2) is a multi-center pilot study to determine if cerebral perfusion imaging can help identify which patients, who are ineligible for intravenous tissue plasminogen activator (iv tPA) therapy or have failed iv tPA therapy, are most likely to benefit from an endovascular clot removal procedure.
Key facts
- Study ID
- NCT01349946
- Run by
- Stanford University
- People needed
- 138
- Starts
- 2008-06-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2016-04-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years and older
- Clinical diagnosis of ischemic stroke and a score of 5 or more points in the NIHSS.
- Planned to undergo intra-arterial (IA) therapy for acute hemispheric stroke (Either as primary therapy or as adjuvant therapy following intravenous tPA treatment)
- Planned to have a standard MRI including perfusion imaging and MR angiography of the circle of Willis (MRA) prior to IA therapy
- Intra-arterial thrombectomy can be started within 90 minutes of completion of MRI scan and within 12 hours of symptom onset. (Start of IA therapy is defined as the time of insertion of the femoral artery sheath; Time of brain scan is defined as the time that the scan is completed)
- Able to obtain informed consent (informed consent should be obtained prior to the baseline MRI scan).
You may not qualify if…
- Any pre-existing neurological illness resulting in a modified Rankin Scale Score of 3 or higher prior to the qualifying stroke
- Pregnancy
Where it is running
- Stanford University School of Medicine — Stanford, California, United States
- The Queen — Honolulu, Hawaii, United States
- Northwestern University — Chicago, Illinois, United States
- Oregon Health Sciences University — Portland, Oregon, United States
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
- University of Utah — Salt Lake City, Utah, United States
- Swedish Hospital — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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