Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants

Status unconfirmed

Conditions studied: Bacteriuria, Urinary Tract Infections, Asymptomatic Infections, Transplantation Infection

In brief

The goal of this research program is to understand the natural history of asymptomatic bacteriuria in the renal transplant patients, to determine if screening for asymptomatic bacteriuria and identification of key host characteristics and virulence factors present on uropathogenic bacteria identifies a sub-population of patients with asymptomatic bacteriuria that are at risk to develop symptomatic urinary tract infection. Ultimately, the knowledge obtained from this study will prevent inappropriate antibiotic use and may identify whether certain bacterial isolates predispose to renal allograft injury. We will test the hypothesis that (i) asymptomatic bacteriuria is common in the renal allograft recipient and (ii) that symptomatic urinary tract infection and renal allograft dysfunction do not occur unless key host susceptibility factors and uropathogenic bacterial virulence factors are present.

Key facts

Study ID

NCT01349738

Run by

Rice, James C., M.D.

People needed

200

Starts

2011-05-01

Expected to finish

2013-05-01

Last updated by the study team

2011-09-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• must be 18 years old or older,
• had a kidney transplant,
• be at least 30 days post operation.

You may not qualify if…

• Pregnant women, those planning to become pregnant or nursing mothers;
• Renal transplant patients less than 30 days post transplant; Use of an indwelling Foley catheter;
• Patients without a renal transplant;
• Patients having concurrent surgical/wound infection and presumed hematogenous dissemination for the urinary tract.

Where it is running

• Scripps Green Hospital — La Jolla, California, United States

Full record on ClinicalTrials.gov

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