Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study

Stopped early · Not applicable

Conditions studied: Obstructive Sleep Apnea, Enlargement of Tonsil or Adenoid

In brief

The aim of this study is to evaluate whether a smaller dose of caffeine sodium benzoate 10 mg/kg IV is as effective as 20 mg/kg IV in decreasing the number of children who develop post extubation adverse upper airway respiratory events compared to placebo.

Key facts

Study ID

NCT01349205

Run by

The University of Texas Health Science Center, Houston

People needed

42

Starts

2010-03-01

Expected to finish

2014-06-01

Last updated by the study team

2016-05-13

Who can join

Age: 2 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children with OSA and/or increased end tidal C02 (sleep related hypoventilation, obstructive hypoventilation or sustained alveolar hypoventilation), 2-12 years of age, and both genders will be eligible to be part of the study. OSA and its severity will be diagnosed by a preoperative polysomnography.

You may not qualify if…

• Children with compromised cardiovascular, pulmonary or renal function, those with congenital syndromes, sickle cell disease, history of seizures and those receiving theophylline will be excluded.

Where it is running

• Memorial Hermann Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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