Human Immune Responses Toward HIV-1 Envelope Antigens
Completed
Conditions studied: HIV Infection
In brief
The primary objectives of this study is to * Define the envelope-specific B-cell and T-cell responses in humans who have received a St. Jude HIV-1 vaccine. * Describe mechanisms of HIV-1 envelope processing and consequent B-cell and T-cell activities.
Key facts
- Study ID
- NCT01344941
- Run by
- St. Jude Children's Research Hospital
- People needed
- 8
- Starts
- 2010-03-01
- Expected to finish
- 2015-11-01
- Last updated by the study team
- 2015-11-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant is greater than or equal to 18 years of age.
- Participant is in good general health.
- Participant weighs ≥ 110 pounds.
- Participant has hemoglobin > 12 gm/dL within last 12 weeks.
- Group 1 (Vaccinees) only Inclusion Criteria:
- Participant has previously received one of the St. Jude HIV-1 vaccines via enrollment in prior St. Jude HIV vaccine studies.
- Group 2 (HIV positive) only Inclusion Criteria:
- Participant is HIV-1 positive by medical record review.
- Group 3 (HIV negative) only Inclusion Criteria:
- Participant is HIV-1 negative as determined by HIV ELISA.
You may not qualify if…
- Participant is unable or unwilling to give written informed consent.
- Participant is pregnant female.
- Group 2 (HIV positive) only Exclusion Criteria:
- Participant is enrolled in other clinical trials that include any blood sampling such that the cumulative blood draws would exceed that established as constituting minimal risk (e.g., more than 550 ml in an 8 week period with collection more frequently than 2 times per week)
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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