Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Completed

Conditions studied: Colon Cancer

In brief

This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.

Key facts

Study ID

NCT01344330

Run by

Texas A&M University

People needed

108

Starts

2012-01-01

Expected to finish

2017-12-01

Last updated by the study team

2020-12-19

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• scheduled for screening colonoscopy
• off NSAID or aspirin therapy in accordance with OHSU endoscopy clinic guidelines
• INR 0.90-1.20
• hemoglobin ≥ 13.5 (men) or 12.0 (women)
• platelets ≥100,000/μL
• Chem screen results within normal limits
• negative (serum or urine) pregnancy test done ≤7 days prior to colonoscopy for women of childbearing potential only
• ASA performance status <2

You may not qualify if…

• history of colon cancer or adenomatous polyps
• current smoker
• medical history of chronic obstructive pulmonary disease
• current oral steroid therapy
• current therapy with valproate or other pharmacological drugs associated with HDAC inhibition
• use of oral antibiotics within 3 months prior to entry into study
• significant active medical illness which in the opinion of the investigator would preclude collection/interpretation of colon tissue
• diagnosis of hemophilia, van Willebrand's disease or other bleeding disorder
• use of warfarin or other blood thinning agents
• inflammatory bowel disease.

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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