Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma
Completed · Not applicable
Conditions studied: Sarcoma
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether surgery is more effective with or without radiation therapy in treating nonmetastatic retroperitoneal soft tissue sarcoma. PURPOSE: This randomized phase III trial is studying radiation therapy followed by surgery to see how well it works compared with surgery alone in treating patients with previously untreated nonmetastatic retroperitoneal soft tissue sarcoma.
Key facts
- Study ID
- NCT01344018
- Run by
- European Organisation for Research and Treatment of Cancer - EORTC
- People needed
- 266
- Starts
- 2012-01-01
- Expected to finish
- 2019-03-01
- Last updated by the study team
- 2023-04-24
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Dana-Farber Cancer Institute & Harvard Medical School — Boston, Massachusetts, United States
- Hopitaux Universitaires Bordet-Erasme - Institut Jules Bordet (101) — Brussels, Belgium
- U.Z. Gasthuisberg — Leuven, Belgium
- Mount Sinai Hospital — Toronto, Ontario, Canada
- CHUM - Centre Hospitalier de l'Université de Montreal - Hopital Notre-Dame — Montreal Quebec, Quebec, Canada
- University Copenhagen — Herlev, Denmark
- Institut Bergonie — Bordeaux, France
- Centre Leon Berard — Lyon, France
- Institut Gustave Roussy — Villejuif, France
- Universitaetsklinikum — Cologne, Germany
- UniversitaetsMedizin Mannheim — Mannheim, Germany
- Klinikum der Universitaet — München, Germany
- Technische Universitaet Muenchen — München, Germany
- Centro Di Riferimento Oncologico — Aviano, Italy
- Istituto Clinico Humanitas — Milan, Italy
- Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Italy
- Istituto Oncologico Veneto — Padova, Italy
- The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis — Amsterdam, Netherlands
- University Medical Center Groningen — Groningen, Netherlands
- Leiden University Medical Centre — Leiden, Netherlands
- Radboud University Medical Center — Nijmegen, Netherlands
- Radium Hospitalet — Oslo, Norway
- Maria Sklodowska-Curie Memorial Cancer Center — Warsaw, Poland
- Hospital General Vall d'Hebron — Barcelona, Spain
- Hospital Universitario San Carlos — Madrid, Spain
Full record on ClinicalTrials.gov
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