Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake

Completed · Phase 4 · Has a placebo group

Conditions studied: Alcohol Abuse

In brief

The overall goals of this study are to (1) expand knowledge about interactions of chlorzoxazone with alcohol by assessing the effects of chlorzoxazone compared to placebo in moderate and heavy social alcohol users and (2) to compare the effects of chlorzoxazone on visual cue induced alcohol craving to placebo in moderate to heavy social alcohol users.

Key facts

Study ID

NCT01342341

Run by

University of California, San Francisco

People needed

48

Starts

2011-04-01

Expected to finish

2013-12-01

Last updated by the study team

2020-11-20

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion Criteria: Healthy adults who are social drinkers 21 - 50 years of age.
• Moderate to heavy social drinkers (women=10-25 drinks/week, men=14-30 drinks/week).
• If female, must be non-lactating, not pregnant, and using a reliable contraception method (i.e. abstinence, intrauterine device [IUD], or hormonal birth control).
• Able and willing to provide written informed consent.
• Able to understand and follow the instructions of the investigator, and understand all rating scales.

You may not qualify if…

• Use of cocaine, amphetamines, hallucinogens, "ecstasy", opiates, sedatives, pain pills, sleeping pills, or other psychoactive drugs more than twice a week.
• A history of complicated alcohol or other drug withdrawal syndrome(s), e.g. delirium tremens or seizures.
• Current physiological dependence on any psychoactive drug (except nicotine or caffeine) including alcohol, as determined by MD or NP assessment.
• Current enrollment in an alcohol or other drug treatment program, or current legal problems relating to alcohol or other drug use, including awaiting trial or supervision by a parole or probation officer.
• Currently trying to quit using alcohol and/or "recreational" drugs.
• Clinically significant medical or psychiatric illness as determined by screening blood tests, medical history, and physical exam performed or reviewed by the study MD or NP.
• Bilirubin more than 2 times the normal upper limit.
• AST (SGOT), ALT (SGPT), or alkaline phosphatase more than 2 ½ times the normal upper limit.
• Symptoms of liver disease, as assessed by MD or NP assessment (jaundice, Hx of hepatitis, itchy skin, etc.).
• A current pregnancy, or a woman of child-bearing potential not currently using an adequate means of contraception.
• BAC level greater than 0.05% at the beginning of Screening Visit, Visit 1 or Visit 4.
• Neurological dysfunction or psychiatric disorder severe enough to interfere with assessment of outcome measures as defined above.
• Known allergy to chlorzoxazone.
• Has received an investigational drug within 30 days prior to Study Visit 2 (after screening visit).
• Subjects who are unable to read or speak English.
• Those who, in the opinion of the investigator, are considered unable to adhere to scheduled appointments, are unlikely to comply with the study protocol, or who are unsuitable for any other reason.

Where it is running

• Ernest Gallo Clinic and Research Center — Emeryville, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.