Proton Radiation Therapy for Invasive Breast Cancer Following Mastectomy

Completed · Not applicable

Conditions studied: Invasive Breast Cancer

In brief

In this study we are looking at a type of radiation called proton radiation which is known to spare surrounding tissue and organs from radiation. The proton radiation will be delivered using 3D conformal proton radiation or scanned beam/IMPT (Intensity Modulated Proton Radiation Treatment). Proton radiation delivers no dose beyond the region requiring treatment. This may reduce side effects that patients would normally experience with conventional radiation therapy or other means of delivering proton radiation therapy. In this study we are evaluating the effectiveness of using proton radiation delivered to reduce side effects association with radiation treatment.

Key facts

Study ID

NCT01340495

Run by

Massachusetts General Hospital

People needed

70

Starts

2011-06-01

Expected to finish

2022-01-03

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed invasive breast cancer confined to the breast and regional lymphatics
• Completed mastectomy (complete not partial )breast surgery +/- reconstructive surgery
• Life expectancy > 12 months

You may not qualify if…

• Pregnant or breast-feeding
• Prior therapeutic radiation > 200 cGy
• History of a different malignancy unless disease-free for at least 5 years or diagnosed and treated cervical cancer in situ, or basal or squamous cell cancer of the skin
• Prior investigation chemotherapy

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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