Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation

Status unconfirmed · Phase 2

Conditions studied: Respiratory Failure, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)

In brief

APRV mode of ventilation will result in an improved partial pressure of arterial oxygenation/ fraction of inspired oxygen (P/F ratio) on day 3 of mechanical ventilation. Sub hypotheses: APRV will be associated with a reduced amount of sedation used during the ICU stay in patients with respiratory failure. APRV will be associated with a reduction in the amount of vasoactive medication used for blood pressure support in patients with respiratory failure.

Key facts

Study ID

NCT01339533

Run by

Intermountain Health Care, Inc.

People needed

246

Starts

2011-10-01

Expected to finish

2016-06-01

Last updated by the study team

2015-08-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hypoxemic respiratory failure requiring mechanical ventilation for >24 hours.

You may not qualify if…

• Age under 18
• Severe chronic obstructive lung disease
• Patients in whom the only indication for mechanical ventilation is airway protection from poor neurological status.

Where it is running

• Intermountain Medical Center — Murray, Utah, United States (enrolling)
• LDS Hospital — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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