ESBA105 in Patients With Severe Dry Eye

Completed · Phase 2 · Has a placebo group

Conditions studied: Eyes Dry Chronic

In brief

The purpose of this study was to evaluate the efficacy of ESBA105 over vehicle in reducing the ocular symptoms of dry eye disease, as measured by a mean global Visual Analog Scale (VAS) discomfort score.

Key facts

Study ID

NCT01338610

Run by

Alcon Research

People needed

334

Starts

2011-06-01

Expected to finish

2012-02-01

Last updated by the study team

2013-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ongoing physician diagnosis of dry eye for at least 6 months.
• Use of artificial tears, gels, lubricants, or re-wetting drops on a regular basis.
• Experience persistent ocular discomfort.
• Other protocol-defined inclusion criteria may apply.

You may not qualify if…

• Contact lens wearers.
• Severe Sjogren's Syndrome.
• History of corneal surgery including refractive surgeries.
• Intraocular surgery within 6 months of Visit 1.
• Intraocular or periocular injection within 6 months of Visit 1.
• Lid function abnormalities.
• Use of steroids, tetracycline, doxycycline, etc., within 30 days of Visit 1.
• Any acute infectious or non-infectious ocular condition of the anterior or posterior segments in either eye within 30 days of Visit 1.
• Diseases/conditions of ocular surface associated with clinically significant scarring/destruction of conjunctiva/cornea.
• Other protocol-defined exclusion criteria may apply.

Where it is running

• Contact Alcon Call Center for Trial Locations — Fort Worth, Texas, United States

Full record on ClinicalTrials.gov

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