Vitamin D Deficiency and Atopic Dermatitis

Stopped early · Not applicable

Conditions studied: Atopic Dermatitis, Vitamin D Deficiency

In brief

Atopic dermatitis is a chronic skin disease characterized by a defective skin barrier, inflammation, and increased propensity for skin infections. Vitamin D is a fat-soluble vitamin that is primarily acquired through local production in the skin after ultraviolet light exposure but can also be obtained through natural and supplemental dietary sources. This randomized controlled trial will examine the effects of vitamin D repletion on atopic dermatitis severity in patients with diagnosed deficiency. The investigators hypothesize that pediatric patients with moderate or severe atopic dermatitis and vitamin D deficiency will have improved cutaneous disease after treatment with high dose as compared to standard dose vitamin D.

Key facts

Study ID

NCT01337635

Run by

Medical College of Wisconsin

People needed

7

Starts

2010-11-01

Expected to finish

2013-04-01

Last updated by the study team

2018-12-05

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Serum 25-hydroxyvitamin D level <20 ng/ml (<50 nmol/L)
• Diagnosed with atopic dermatitis by a CHW pediatric dermatologist
• Age 1-18 years old
• Primary residence in Milwaukee County
• Moderate and severe atopic dermatitis (Severity Scoring of Atopic Dermatitis [SCORAD] score greater than 15)
• On clinic protocol treatment for their atopic dermatitis (desonide ointment twice daily for the face and groin, triamcinolone 0.1% ointment twice daily for other areas)

Where it is running

• Children's Hospital of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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