Exercise and Inflammation

Completed · Not applicable

Conditions studied: Cardiovascular Disease

In brief

The purpose of this study is to test the hypothesis that aerobic exercise leads to attenuation of the inflammatory response to lipopolysaccharide (LPS) stimulation.

Key facts

Study ID

NCT01335737

Run by

New York State Psychiatric Institute

People needed

241

Starts

2010-01-01

Expected to finish

2015-04-01

Last updated by the study team

2018-06-11

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 20-45 years old
• English-speaking
• Ambulatory
• BMI < 32
• Pre-menopausal (women only) with regular cycle lengths between 26-32 days
• "Average" fitness as determined by American Heart Association standards (VO2max < 43 ml/kg/min for men, < 37 ml/kg/min for women) VO2max test

You may not qualify if…

• Use of anti-psychotic medications
• Current of past major depressive disorder, or total symptom score > 10
• BMI<18
• Heart disease
• Hypertension
• Diabetes mellitus
• Neurologic disease
• Smoking
• Individuals with ischemic heart disease, cardiac arrhythmias, peripheral vascular disease, orthopedic problems such as foot, leg, hip and spine problems,movement disorders, other neurological disorders affecting gait or balance, conditions or treatments associated with impaired thermoregulation, or other medical problems, for which aerobic training would be contraindicated.
• Use of any medication with autonomic effects
• Use of birth control medication
• Ischemic changes, abnormal blood pressure responses, significant ectopy
• Appears to be at high risk to be unable to adhere to study protocol

Where it is running

• Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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