Executive Dysfunction and Self-Harm Behavior: An Examination of Veterans With TBI, PTSD, or Both

Completed

Conditions studied: Traumatic Brain Injury, Post Traumatic Stress Disorder, Suicide, Self-Injurious Behavior

In brief

1. To determine whether tasks taken from the field of cognitive neuroscience can detect and distinguish impairments in executive function above and beyond standard neuropsychological measures in individuals with: a.) Mild Traumatic Brain Injury (TBI), b.) Post Traumatic Stress Disorder (PTSD), c.)Mild TBI+PTSD 2. To determine whether performance on these tasks is linked to pertinent psychiatric outcomes (e.g. history of suicidality), which is associated with compromised executive function and impulsivity. 3. To determine whether information regarding brain anatomy can provide additional information above and beyond behavior performance in distinguishing between these two groups.

Key facts

Study ID

NCT01334463

Run by

VA Eastern Colorado Health Care System

People needed

186

Starts

2010-07-01

Expected to finish

2016-01-01

Last updated by the study team

2016-01-25

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 18-45 years old
• At least one OEF/OIF deployment
• Currently receiving or eligible to receive physical and/or mental health care through the VA Eastern Colorado Health Care System

You may not qualify if…

• History of other significant neurological disease (other than mild TBI for the appropriate groups) as assessed by interview and chart review
• History or diagnosis of lifetime moderate or severe TBI for the TBI groups, or any history of TBI for the non-TBI groups, as assessed by interview and chart review
• History or diagnosis of non-active duty-related mild TBI or PTSD disorder as assessed by interview and/or chart review
• Diagnosis of schizophrenia or bipolar I disorder as assessed by interview and/or chart review
• Computerized Assessment of Response Bias (CARB) performance categorized as Very Poor or Symptom Exaggerator
• Problematic drinking behavior that consistently exceeds recommended drinking limits per day, e.g., Diagnosis of Alcohol Abuse Disorder or Alcohol Dependence Disorder per the SCID; or five or more alcoholic drinks per day, four out of seven days per week for the previous two weeks
• Use of illicit substance(s) more than five times in the two weeks before enrollment
• Inability to read the informed consent document or adequately respond to questions regarding the informed consent procedure
• Contraindication to having an MRI

Where it is running

• Denver VA Medical Denver — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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