An In-vitro Standardization of B Cell Elispot Assays

Stopped early

Conditions studied: Transplant Sensitization, Panel Reactive Antibody, Sensitization to HLA Antigens

In brief

This study is being done because the study doctor is trying to develop a new test which will help transplant doctors monitor patients with high panel reactive antibodies (PRA). The test would be used to monitor patients' PRA when doctors are trying to lower it through a process known as desensitization. Desensitization lowers high PRA levels and allows patients to receive transplants. This is a single center study to evaluate and optimize the use of a new laboratory test to detect and measure the immune system's functioning.

Key facts

Study ID

NCT01334281

Run by

Northwestern University

People needed

19

Starts

2008-02-01

Expected to finish

2012-10-01

Last updated by the study team

2013-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects should be listed for solid organ transplant at NU/NMH
• Subjects should be > or = to 18 years of age, either gender
• Subjects should have history of prior sensitization of HLA antigens
• Subjects should have documented antibody specificity previously tested at the transplant immunology lab at NU
• Subjects should be capable of understanding the study, consents, HIPAA process and be able to give informed consent.

You may not qualify if…

• Subjects younger than 18 years of age
• Subjects with no sensitization history

Where it is running

• Northwestern Memorial Hospital — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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