cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose

Completed · Not applicable

Conditions studied: Olfactory Disorder

In brief

The purpose of this study is to determine the normal distribution of nasal tissue cathelicidin antimicrobial peptides (cAMP) levels in subjects with normal smell and subjects with smell dysfunction. The investigators will also look at the effect of nasal saline irrigation on olfaction and cAMP levels and if nasal irrigation is capable of harvesting olfactory cilia. The investigators hypothesize that nasal saline will have no effect on olfaction and will be inadequate to harvest olfactory cilia.

Key facts

Study ID

NCT01332825

Run by

University of Washington

People needed

41

Starts

2011-03-01

Expected to finish

2012-12-01

Last updated by the study team

2013-12-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal olfactory function cohort:
• self-reported normal smell function
• age greater than 18 years
• Olfactory dysfunction cohort:
• ICD9 diagnostic code for olfactory dysfunction
• idiopathic olfactory dysfunction
• age greater than 18 years

You may not qualify if…

• allergy to lidocaine
• active upper respiratory infection
• previous nasal or sinus surgery
• current tobacco use
• unable to give consent due to language barrier, cognitive or medical issues

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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