Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis

Completed

Conditions studied: Chronic Rhinosinusitis

In brief

This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.

Key facts

Study ID

NCT01332136

Run by

Oregon Health and Science University

People needed

966

Starts

2011-04-01

Expected to finish

2016-03-01

Last updated by the study team

2016-03-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (>= 18 years)
• Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines
• Able to complete all surveys/questionnaires in English
• Persistent symptoms following initial medical management
• Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days
• Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy.
• Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery

You may not qualify if…

• Children (<18 years)
• Unable to complete all surveys/questionnaires at baseline

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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