Mechanisms and Treatment Response of Aggressive Periodontitis in Children

Completed · Not applicable

Conditions studied: Aggressive Periodontitis

In brief

Although of low prevalence, aggressive periodontitis is a rapid destructive form of periodontal disease that initiates at a young age, leading to premature loss of first molars and incisors. Little is known on the mechanisms of this disease. It is imperative to understand mechanisms of disease to establish proper treatment. We have established a controlled study in a comparable population presenting similar aggressive disease characteristics to evaluate the mechanisms of this disease. It is the goal of this study to determine immunological and microbiological mechanisms responsible for the rapid tissue destruction in children with localized aggressive periodontitis and how traditional periodontal intervention affects these mechanisms. Important knowledge gained with this proposal will aid in defining specific treatment approaches to better control disease progression and prevent disease initiation in susceptible individuals.

Key facts

Study ID

NCT01330719

Run by

University of Florida

People needed

514

Starts

2006-12-01

Expected to finish

2022-12-02

Last updated by the study team

2024-03-12

Who can join

Age: 5 and older, up to 90. Sex: any. Healthy volunteers: accepted.

Where it is running

• Acorn Dental Clinic — Brooker, Florida, United States
• Broward College — Fort Lauderdale, Florida, United States
• Dental Clinical Research Unit, University of Florida — Gainesville, Florida, United States
• Azalea Dental Clinic — Gainesville, Florida, United States
• UF Hialeah Dental Clinic — Hialeah, Florida, United States
• Duval County Department of Health — Jacksonville, Florida, United States
• UF Naples Pediatric Dental Clinic — Naples, Florida, United States
• Gadsden County Health Department--Quincy Dental Clinic — Quincy, Florida, United States
• Leon County Health Department — Tallahassee, Florida, United States
• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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