FOB in HSCT and Leukemia Patients With Acute Respiratory Symptoms and Pulmonary Infiltrates

Completed · Not applicable

Conditions studied: Pulmonary Infiltrate New

In brief

Pulmonary infiltrates frequently complicate the care of hematopoietic stem cell transplant (HSCT) and leukemia patients. Bronchoalveolar lavage (BAL) is frequently used to evaluate new pulmonary infiltrates in this population, however utility is limited by a historically low diagnostic yield for infection. In an effort to improve diagnostic yields, this study will complete a Fiberoptic Bronchoscopy (FOB) within 8 hours of radiographic documentation of pulmonary infiltrates, prior to initiating new antibiotic therapy. To further improve detection of microbiological pathogens, the study will utilize PCR testing with rapid turnaround time to detect atypical pneumonia (M pneumoniae, C. Pneumonia, Legionella species, and respiratory viruses) and aspergillosis.

Key facts

Study ID

NCT01328873

Run by

Northside Hospital, Inc.

People needed

49

Starts

2011-03-01

Expected to finish

2017-04-01

Last updated by the study team

2017-07-11

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Autologous or allogeneic stem cell patients with new acute respiratory symptoms or pulmonary infiltrates
• leukemia patients with new acute respiratory symptoms or pulmonary infiltrates thought to be unrelated to disease

You may not qualify if…

• Patients unwilling to undergo FOB
• Patients unable to undergo FOB due to clinical status
• Patients unable to undergo FOB within 8 hours of radiographic report of pneumonia
• Patients unable to wait until completion of FOB to implement antibiotic changes
• Adults unable to provide informed consent

Where it is running

• Northside Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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