Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease
Completed · Not applicable
Conditions studied: Non Alcoholic Fatty Liver Disease
In brief
The central hypothesis of this proposal is that a reduction in hepatic mitochondrial function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle modifications through aerobic exercise training without weight loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content and function in human subjects. The investigators propose a randomized, controlled human clinical trial to compare the effects of aerobic exercise training (without weight loss) versus diet-induced weight loss (without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
Key facts
- Study ID
- NCT01327443
- Run by
- University of Missouri-Columbia
- People needed
- 17
- Starts
- 2010-10-01
- Expected to finish
- 2015-10-01
- Last updated by the study team
- 2016-10-05
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- sedentary individual between
- age group 18-60 years old
- elevated Liver Function Tests (LFT's) with fatty liver on ultrasound and biopsy proven NASH
You may not qualify if…
- significant history of alcohol consumption > 20 gm/day (> 2 drinks / day)
- evidence of other causes of hepatitis including positive screening B \& C, autoimmune hepatitis, hemochromatosis, celiac disease, Wilson's disease, alpha 1 antitrypsin deficiency or medication-induced hepatitis
- Subjects with planned exercise > 30-60 minutes per week
- BMI < 25 or > 44 kg/m2
- clinical or biochemical evidence of decompensated liver disease, advanced cardiac or renal disease
- changes in last 3 months the dose of oral hypoglycemic medication and statin,
- positive stress test
- pregnant women
- demented individuals who cannot give consent
Where it is running
- University Hospital — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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