Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis

Status unconfirmed

Conditions studied: Anaphylaxis

In brief

Anaphylaxis is a serious allergic reaction that develops rapidly and can cause death. Some patients experience anaphylaxis is association with exercise, a disorder called exercise-induced anaphylaxis. A subset of patients with unexplained anaphylaxis, especially those with hypotension during the anaphylactic episodes, have been shown to have abnormal, clonal populations of a certain cell type, mast cells, in the bone marrow. This has been described in at least one patient with exercise-induced anaphylaxis. The investigators would like review the findings in a group of patients with exercise-induced anaphylaxis who have undergone evaluation for the presence of abnormal, clonal mast cells.

Key facts

Study ID

NCT01326741

Run by

Brigham and Women's Hospital

People needed

10

Starts

2011-03-01

Last updated by the study team

2011-03-31

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Anaphylaxis in association with exercise on at least two occasions
• During anaphylactic reaction, the subject must have experienced one or more of the following: flushing, hypotension, lack of urticaria

You may not qualify if…

• Pregnancy

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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