Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)

Stopped early

Conditions studied: Resuscitation, Trauma Patients

In brief

This study involved the medical record review of resuscitation records for all severely-injured trauma patients requiring emergent surgical intervention and significant acidosis from 2005 through 2009.

Key facts

Study ID

NCT01326260

Run by

University of California, San Francisco

People needed

60

Starts

2010-07-01

Expected to finish

2015-05-01

Last updated by the study team

2020-02-17

Who can join

Age: 1 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presence of severe traumatic injury requiring emergent surgery
• Peri-operative development of severe acidosis (defined arterial ph less than or equal to 7.20 or base deficit greater than or equal to 10 mEq/dL)
• Acidosis was treated with either THAM or "usual care" (defined as crystalloid either or without sodium bicarbonate)

You may not qualify if…

• None

Where it is running

• University of California, San Francisco at San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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