Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet

Completed · Not applicable

Conditions studied: Salt-sensitive Hypertension

In brief

The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril. In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.

Key facts

Study ID

NCT01324245

Run by

Georgetown University

People needed

45

Starts

2002-11-01

Expected to finish

2006-05-01

Last updated by the study team

2011-03-28

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Volunteers
• Healthy
• Normal Blood Pressure

You may not qualify if…

• Renal Impairment
• Obesity
• Salt sensitive increase in blood pressure

Where it is running

• Georgetown University Medical Center — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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