Diagnostic Algorithm in Suspected Upper Extremity Deep Vein Thrombosis

Completed · Not applicable

Conditions studied: Suspected Upper Extremity Deep Vein Thrombosis

In brief

Deep vein thrombosis (DVT) of the arm, officially called upper extremity DVT is a rare disorder and accounts for up to 1-4% of all cases of deep vein thrombosis. In case of a thrombosis, there is a blood clot in one of the veins, which should be treated with blood thinners (anticoagulants). The aim of the present study is to see whether it is safe to use a combination of tests for the diagnosis of arm thrombosis. In all patients, we will use a clinical decision rule (clinical judgement) and a laboratory test (D-dimer testing), in most patients also an ultrasound of the arm will be done. The combination of these tests was found to be safe and effective in patients with thrombosis of the legs.

Key facts

Study ID

NCT01324037

Run by

University Medical Center Groningen

People needed

406

Starts

2010-03-01

Expected to finish

2013-04-01

Last updated by the study team

2014-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients from the emergency department, in and out patient clinic with clinically suspected upper extremity deep vein thrombosis

You may not qualify if…

• No informed consent obtained
• Legal age limitation (country specific)
• Use of anticoagulants in therapeutic dosages longer than 24 hours prior to randomisation
• Prior vein thrombosis in the same arm
• Life expectancy < 3 months
• Haemodynamic instability
• Previous participation in the study

Where it is running

• Veterans Affairs Hospital — Washington D.C., District of Columbia, United States
• Medical University Graz — Graz, Austria
• Medical University Innsbruck — Innsbruck, Austria
• University Hospital Leuven — Leuven, Belgium
• University Hospital Dresden — Dresden, Germany
• Ospedali Riuniti — Bergamo, Italy
• University Hospital Bologna — Bologna, Italy
• Hospital D'Annunziata — Chieti, Italy
• University Hospital of Padova — Padova, Italy
• Servizio Sanitario Regionale Emilia - Romagna — Reggio Emilia, Italy
• Rijnstate Hospital — Arnhem, Gelderland, Netherlands
• Onze Lieve Vrouwe Gasthuis — Amsterdam, Netherlands
• Slotervaart Hospital — Amsterdam, Netherlands
• Maxima Medisch Centrum — Eindhoven/Veldhoven, Netherlands
• University Medical Center Groningen — Groningen, Netherlands
• Academic Hospital Maastricht — Maastricht, Netherlands
• Antonius Hospital — Nieuwegein, Netherlands
• Geneva University Hospital — Geneva, Switzerland

Full record on ClinicalTrials.gov

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