Effectiveness of Celecoxib After Surgical Sperm Retrieval

Stopped early · Not applicable · Has a placebo group

Conditions studied: Pain

In brief

While narcotic medication are commonly used for pain control near the time of surgery, there are significant side effects including constipation, nausea, risk of overdose leading to decreased breathing, and risk of addiction to narcotics. Our goal is to explore alternatives to narcotics for perioperative pain for patients undergoing sperm retrieval surgery. We have designed a prospective randomized clinical trial to evaluate how effective the anti-inflammatory medicine celecoxib(Celebrex©) is for pain control near the time of surgery. Celecoxib is known as a COX-2 inhibitor, a drug that belongs to the non-steroidal anti-inflammatory drug (NSAID) class. It is used to reduce swelling and to treat pain. Patients will be divided into two groups: the first group receives a celecoxib pill and the second group receives a sugar pill(placebo). Patients and doctors will be unaware of exactly which pills are given. The patient will complete questionnaires for pain level. By comparing the pain levels we can better understand whether celecoxib (Celebrex©) significantly decreases perioperative pain.

Key facts

Study ID

NCT01323595

Run by

Weill Medical College of Cornell University

People needed

78

Starts

2011-01-01

Expected to finish

2013-03-01

Last updated by the study team

2018-10-02

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• >/= 18 years old
• Male
• Scheduled to undergo microdissection testicular sperm extraction

You may not qualify if…

• History of allergies to celecoxib (Celecoxib)
• Renal failure
• History of ulcer disease
• Any history of myocardial infarction
• Any history of stroke
• History of bleeding diathesis
• Use of aspirin

Where it is running

• Department of Urology, Weill Cornell Medical College, — New York, New York, United States

Full record on ClinicalTrials.gov

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