National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
Completed
Conditions studied: Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation, Bicuspid Aortic Valve Without Known Family History, Bicuspid Aortic Valve With Family History, Bicuspid Aortic Valve With Coarctation, Familial Thoracic Aortic Aneurysm and Dissections, Shprintzen-Goldberg Syndrome, Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo, Other Congenital Heart Disease
In brief
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac/.
Key facts
- Study ID
- NCT01322165
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 3706
- Starts
- 2007-11-01
- Expected to finish
- 2016-09-01
- Last updated by the study team
- 2016-12-20
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Inability of the patient, parent or guardian to give consent.
- Unwillingness to provide a blood or buccal specimen.
Where it is running
- Queens Medical Center — Honolulu, Hawaii, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- The New York Presbyterian Hospital-Weill Cornell Medical Center — New York, New York, United States
- Oregon Health & Science University — Portland, Oregon, United States
- University of Pennsylvania School of Medicine — Philadelphia, Pennsylvania, United States
- Baylor College of Medicine — Houston, Texas, United States
- University of Texas Medical School at Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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