Preventive Treatment of Episodic and Chronic Migraine

Status unconfirmed · Phase 4

Conditions studied: Migraine With Aura, Migraine Without Aura, Chronic Migraine

In brief

This is an open label pilot study to determine whether milnacipran can reduce headache frequency in episodic and chronic migraine sufferers.

Key facts

Study ID

NCT01319825

Run by

California Medical Clinic for Headache

People needed

45

Starts

2011-04-01

Expected to finish

2012-07-01

Last updated by the study team

2011-03-22

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Migraine with or without aura or chronic migraine.
• Subject age 18 to 70.
• At least 2 migraine attacks per month.
• Willing ang able to give written informed consent.
• Willing and able to complete the entire course of the study and to comply with study instructions.
• Willing to taper and discontinue their current preventive medications.

You may not qualify if…

• Subject is pregnant, lactating or planning a pregnancy in the next year.
• Subject is female of child-bearing potential and not taking adequate forms of birth control.
• Significant medical or psychiatric disease or abnormal laboratory data that would preclude entry into this study.
• Previous failure of four or more adequate trials of preventive medication.
• Currently on any form of antidepressant for depression and not able to discontinue.
• Currently demonstrating medication overuse headache.
• Currently has uncontrolled narrow angle glaucoma.
• Currently taking monoamine oxidase inhibitors.
• Subject has a history of seizures.
• Participation in an investigational drug study within the last 30 days or 5 half-lives, whichever is longer.

Where it is running

• California Medical Clinic for Headache — Santa Monica, California, United States

Full record on ClinicalTrials.gov

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