Fresh Versus Old Red Blood Cells for Transfusion

Completed · Not applicable

Conditions studied: Iron, Abnormal Blood Level, Other Abnormal Blood Chemistry

In brief

Packed red blood cell units destined for transfusion can be stored for up to 42 days prior to transfusion based on Food and Drug Administration (FDA) guidelines. Recent studies suggest that certain patients transfused with blood stored for longer duration have poorer outcomes than patients transfused fresher blood. The investigators' hypothesis is that the delivery of an immediate and substantial load of hemoglobin-associated iron from a stored unit of blood leads to changes that explain the differences in outcome between patients transfused old versus fresh blood. The investigators propose to test this hypothesis in humans by transfusing an individual's own blood, both fresh and after storage, and comparing levels of various outcome measures.

Key facts

Study ID: NCT01319552
Run by: Columbia University
People needed: 14
Starts: 2008-12-01
Expected to finish: 2010-10-01
Last updated by the study team: 2015-06-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

healthy
male body weight >130 lbs, female body weight > 155 lbs
male height >5'1", female height >5'5"
hemoglobin >13.3 g/dL

You may not qualify if…

ineligible for donation based on the New York Blood Center autologous blood donor questionnaire
systolic blood pressure >180 or <90 mm Hg
diastolic blood pressure >100 or <50 mm Hg
heart rate <50 or >100
temperature >99.5 F prior to donation
temperature >100.4 F or subjective feeling of illness prior to transfusion
positive results on standard blood donor infectious disease testing
pregnancy.

Where it is running

Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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